Coexistence of several unbalanced translocations in a case of neuroblastoma: The contribution of multicolor spectral karyotyping

Luba Trakhtenbrot, Ninette Cohen, Esther Rosner, Nelly Gipsh, Frida Brok-Simoni, Matilda Mandel, Ninette Amariglio, Gideon Rechavi

Research output: Contribution to journalArticlepeer-review

Abstract

Spectral karyotyping (SKY) is based on the simultaneous hybridization of a set of 24 chromosome-specific DNA painting probes, each labeled with a different fluor combination. Automatic classification, based on the measurement of the spectrum for each chromosome, was applied to metaphases obtained from the affected bone marrow of a neuroblastoma case. Spectral karyotyping allowed the identification of chromosomal aberrations that could not be identified by the use of the G-banding technique, and revealed a number of gains and unbalanced translocations. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume112
Issue number2
DOIs
StatePublished - 15 Jul 1999
Externally publishedYes

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