Coexistence of malignancies in pemphigus vulgaris

Karin Warshavsky, Tal Zeeli, Ori Mekiten, Eli Sprecher, Barbara G. Silverman, Aviv Barzilai, Sharon Baum*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Pemphigus vulgaris (PV) is a rare autoimmune intraepidermal bullous disease. PV has a major effect on morbidity as well as quality of life. There is sparse literature regarding the association between pemphigus vulgaris (PV) and comorbid malignancies. In this study we aimed to assess the risk of malignancy in a cohort of patients with PV and characterize PV-associated malignancies. Data were collected from two tertiary referral centers between the years 2008 and 2019 and compared with the national cancer registry. Of 164 patients with PV, 19 were diagnosed with malignancy: seven prior to PV diagnosis and 12 after. All cancers, solid and hematological, displayed higher incidences compared to the general population (p <0.001). In conclusion, we demonstrated higher rates of malignancies among patients with PV than in the general population. These observations suggest the need for careful assessment and follow up of patients with PV, given the possibility of associated malignancies.

Original languageEnglish
Pages (from-to)743-748
Number of pages6
JournalImmunologic Research
Issue number5
StatePublished - Oct 2023


  • Immune suppression
  • Malignancy
  • Pemphigus
  • Tumors


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