TY - JOUR
T1 - Cocaine, but not amphetamine, short term treatment elevates the density of rat brain vesicular monoamine transporter 2
AU - Schwartz, K.
AU - Nachman, R.
AU - Yossifoff, M.
AU - Sapir, R.
AU - Weizman, A.
AU - Rehavi, M.
PY - 2007/4
Y1 - 2007/4
N2 - We compared the effect of 5 days D-amphetamine (5 mg/kg/day i.p.) and cocaine (15 mg/kg/day i.p.) administration on the vesicular monoamine transporter 2 (VMAT2) density in rat brain. VMAT2 expression was assessed by [3H]dihydrotetrabenazine high affinity binding. Cocaine administration led to significant increases in VMAT2 density in both prefrontal cortex (+40%, p < 0.01) and striatum (+23%, p < 0.05), while amphetamine did not affect VMAT2 expression. The upregulation of VMAT2 may serve as compensatory mechanism aimed to enhance the vesicular monoamine storage capacity.
AB - We compared the effect of 5 days D-amphetamine (5 mg/kg/day i.p.) and cocaine (15 mg/kg/day i.p.) administration on the vesicular monoamine transporter 2 (VMAT2) density in rat brain. VMAT2 expression was assessed by [3H]dihydrotetrabenazine high affinity binding. Cocaine administration led to significant increases in VMAT2 density in both prefrontal cortex (+40%, p < 0.01) and striatum (+23%, p < 0.05), while amphetamine did not affect VMAT2 expression. The upregulation of VMAT2 may serve as compensatory mechanism aimed to enhance the vesicular monoamine storage capacity.
KW - Amphetamine
KW - Cocaine
KW - Prefrontal cortex
KW - Striatum
KW - Vesicular monoamine transporter 2 (VMAT2)
UR - http://www.scopus.com/inward/record.url?scp=33947496041&partnerID=8YFLogxK
U2 - 10.1007/s00702-006-0549-8
DO - 10.1007/s00702-006-0549-8
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AN - SCOPUS:33947496041
SN - 0300-9564
VL - 114
SP - 427
EP - 430
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 4
ER -