Cobalt phthalocyanine as a mediator for the electrooxidation of glucose oxidase at glucose electrodes

I. Rosen-Margalit, A. Bettelheim, J. Rishpon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A method for the construction of a highly stable enzyme electrode is described. A new mediator, cobalt phthalocyanine, a biocompatible material, was immobilized together with the enzyme glucose oxidase in a colloidal graphite emulsion matrix. The resulting glucose electrode was characterized. The electrode retains its full activity for long periods (more than 11 months). The response to glucose is high, fast and independent of ph (5-8) or oxygen partial pressure. The linear range obtained (0-5 mM) can be extended by the introduction of a dialysis membrane and can thus be adjustedto the measurement of glucose concentrations in the range of medical interest. The electrode was tested successfully on serum samples.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalAnalytica Chimica Acta
Volume281
Issue number2
DOIs
StatePublished - 10 Sep 1993

Keywords

  • Amperometry
  • Cobalt phthalocyanine
  • Enzymatic methods
  • Enzyme electrodes
  • Glucose

Fingerprint

Dive into the research topics of 'Cobalt phthalocyanine as a mediator for the electrooxidation of glucose oxidase at glucose electrodes'. Together they form a unique fingerprint.

Cite this