Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloidosis

Batia Kaplan, Brian M. Martin, Olga Boykov, Rivka Gal, Mordechai Pras, Itzhak Shechtman, Milton Saute, Mordechai R. Kramer

Research output: Contribution to journalArticlepeer-review

Abstract

Localized pulmonary amyloidosis is a rare condition whose pathogenesis is insufficiently understood. In the present study, we report a case of localized pulmonary amyloidosis associated with lung-restricted lymphoplasmacytoid lymphoma, monoclonal for immunoglobulin (Ig) G lambda (λ). Biochemical microtechniques have been applied for extraction, purification, and characterization of amyloid proteins. Surprisingly, chemical analysis of these proteins revealed a not-previously-described case of combined deposits containing Ig fragments of gamma heavy chain (variable domain) and λ light chain (constant domain). In view of the absence of circulating monoclonal Ig, this case supports the hypothesis that localized amyloid is formed by local plasmacytoid cells.

Original languageEnglish
Pages (from-to)756-761
Number of pages6
JournalVirchows Archiv
Volume447
Issue number4
DOIs
StatePublished - Oct 2005

Keywords

  • Amyloid
  • Immunoglobulin light and heavy chains
  • Microtechniques
  • Pulmonary amyloidosis

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