Co-Assembly Induced Solid-State Stacking Transformation in Amino Acid-Based Crystals with Enhanced Physical Properties

Wei Ji*, Hui Yuan, Bin Xue, Sarah Guerin, Hui Li, Lei Zhang, Yanqing Liu, Linda J.W. Shimon, Mingsu Si, Yi Cao, Wei Wang, Damien Thompson, Kaiyong Cai, Rusen Yang*, Ehud Gazit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The physical characteristics of supramolecular assemblies composed of small building blocks are dictated by molecular packing patterns in the solid-state. Yet, the structure–property correlation is still not fully understood. Herein, we report the unexpected cofacial to herringbone stacking transformation of a small aromatic bipyridine through co-assembly with acetylated glutamic acid. The unique solid-state structural transformation results in enhanced physical properties of the supramolecular organizations. The co-assembly methodology was further expanded to obtain diverse molecular packings by different bipyridine and acetylated amino acid derivatives. This study presents a feasible co-assembly approach to achieve the solid-state stacking transformation of supramolecular organization and opens up new opportunities to further explore the relationship between molecular arrangement and properties of supramolecular assemblies by crystal engineering.

Original languageEnglish
Article numbere202201234
JournalAngewandte Chemie - International Edition
Volume61
Issue number17
DOIs
StatePublished - 19 Apr 2022

Funding

FundersFunder number
European Research Council
Science Foundation Ireland12/RC/2275 P2, 15/CDA/3491
Science Foundation Ireland
National Natural Science Foundation of China52103148, 51973170, 11804148
National Natural Science Foundation of China
Chongqing University
Natural Science Foundation of Jiangsu ProvinceBK20180320
Natural Science Foundation of Jiangsu Province
Horizon 2020694426
Horizon 2020
Fundamental Research Funds for the Central Universities020414380187, 2021CDJQY‐021
Fundamental Research Funds for the Central Universities

    Keywords

    • Amino Acids
    • Co-Assembly
    • Stacking Modes
    • Supramolecular Chemistry

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