Clusters of male and female Alzheimer’s disease patients in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database

Dragan Gamberger*, Bernard Ženko, Alexis Mitelpunkt, Netta Shachar, Nada Lavrač

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

This paper presents homogeneous clusters of patients, identified in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 biological and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer’s disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes.

Original languageEnglish
Pages (from-to)169-179
Number of pages11
JournalBrain Informatics
Volume3
Issue number3
DOIs
StatePublished - 1 Sep 2016

Funding

FundersFunder number
DOD ADNI
InnoMol project
National Institutes of HealthU01 AG024904
U.S. Department of DefenseW81XWH-12-2-0012
National Institute on Aging
National Institute of Biomedical Imaging and Bioengineering
Alzheimer's Disease Neuroimaging Initiative
Seventh Framework Programme316289, 604102, 612944
European Commission
Javna Agencija za Raziskovalno Dejavnost RS
Hrvatska Zaklada za Znanost9623

    Keywords

    • Alzheimer’s disease
    • Clustering
    • Female and male subpopulations

    Fingerprint

    Dive into the research topics of 'Clusters of male and female Alzheimer’s disease patients in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database'. Together they form a unique fingerprint.

    Cite this