Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine

RenéS S. Kahn; Michael Davidson; Larry J. Siever; Serge Sevy; Kenneth L. Davis

doi:10.1016/0006-3223(94)91236-X

Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine

RenéS S. Kahn^*
, Michael Davidson
, Larry J. Siever
, Serge Sevy
, Kenneth L. Davis

^*Corresponding author for this work

VA Medical Center

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.

Original language	English
Pages (from-to)	909-912
Number of pages	4
Journal	Biological Psychiatry
Volume	35
Issue number	12
DOIs	https://doi.org/10.1016/0006-3223(94)91236-X
State	Published - 15 Jun 1994
Externally published	Yes

Keywords

Schizophrenia
clozapine
hormones
mCPP
serotonin

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10.1016/0006-3223(94)91236-X

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title = "Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine",

abstract = "The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.",

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AU - Kahn, RenéS S.

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AU - Siever, Larry J.

AU - Sevy, Serge

AU - Davis, Kenneth L.

PY - 1994/6/15

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AB - The effects of clozapine treatment on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine (mCPP) were examined. mCPP and placebo were administered after a 2-week drug-free period and again after 5 weeks of clozapine treatment in nine schizophrenic inpatients. Adrenocorticotropic hormone (ACTH), prolactin, and mCPP levels were measured. Clozapine treatment completely blocked mCPP-induced ACTH and prolactin release suggesting that clozapine blocks serotonin receptors that mediate these hormone responses.

KW - Schizophrenia

KW - clozapine

KW - hormones

KW - mCPP

KW - serotonin

UR - https://www.scopus.com/pages/publications/0028302345

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JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 12

ER -

Clozapine treatment and its effect on neuroendocrine responses induced by the serotonin agonist, m-chlorophenylpiperazine

Abstract

Keywords

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