Clozapine: Pharmacokinetics and pharmacodynamics

Amir Krivoy*, Abraham Weizman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The pharmacological properties of clozapine have been studied for more than 60 years. A plethora of information has been accumulated on its metabolism in the human body and on its effects on the neuronal system, both in the brain and in the peripheral nervous system. The complexity of the drug is manifested both in its multi-factorial metabolism as well as in its broad activity on numerous neurotransmitter systems. Yet, the unique mechanism of action of clozapine in treatmentresistant schizophrenia is unknown. In this chapter, clozapine’s metabolism, bioavailability at the synapses and effects on neurotransmission are described. These data can hopefully guide clinicians in optimising clozapine treatment and in managing drug interactions and adverse effects in a precise and personalised manner.

Original languageEnglish
Title of host publicationClozapine
Subtitle of host publicationMedical Uses, Interactions and Side Effects
PublisherNova Science Publishers, Inc.
Number of pages25
ISBN (Electronic)9781536169928
StatePublished - 1 Jan 2020


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