TY - JOUR
T1 - Clozapine for the treatment of agitated-depressed patients with cognitive impairment
T2 - A report of three cases
AU - Nacasch, Nitza
AU - Dolberg, Ornah T.
AU - Hirschmann, Schmuel
AU - Dannon, Pinhas
AU - Grunhaus, Leon J.
PY - 1998
Y1 - 1998
N2 - Clozapine, an atypical antipsychotic, is mainly approved for the treatment of resistant schizophrenia. However, a substantial body of evidence suggests that it might be useful in other psychiatric indications, such as treatment-resistant depression, Parkinson's disease, and dementia. In this report we present the cases of three patients hospitalized at the psychiatric division of the Sheba Medical Center, diagnosed with major depressive disorder with cognitive impairment, whose presenting symptom was agitation. These patients were nonresponders to various treatment modalities. However, treatment with clozapine brought about a favorable response.
AB - Clozapine, an atypical antipsychotic, is mainly approved for the treatment of resistant schizophrenia. However, a substantial body of evidence suggests that it might be useful in other psychiatric indications, such as treatment-resistant depression, Parkinson's disease, and dementia. In this report we present the cases of three patients hospitalized at the psychiatric division of the Sheba Medical Center, diagnosed with major depressive disorder with cognitive impairment, whose presenting symptom was agitation. These patients were nonresponders to various treatment modalities. However, treatment with clozapine brought about a favorable response.
KW - Agitation
KW - Atypical antipsychotics
KW - Clozapine
KW - Major depression
UR - http://www.scopus.com/inward/record.url?scp=0031954675&partnerID=8YFLogxK
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C2 - 9579302
AN - SCOPUS:0031954675
SN - 0362-5664
VL - 21
SP - 132
EP - 134
JO - Clinical Neuropharmacology
JF - Clinical Neuropharmacology
IS - 2
ER -