TY - JOUR
T1 - Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels
AU - Nechmad, Allon
AU - Maayan, Rachel
AU - Ramadan, Edward
AU - Morad, Oren
AU - Poyurovsky, Michael
AU - Weizman, Abraham
PY - 2003/1
Y1 - 2003/1
N2 - We examined the influence of the atypical antipsychotic agent clozapine compared to haloperidol, on levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate ester (both γ-aminobutyric acidA (GABAA) receptor allosteric antagonists) in the rat cortex. i.p. injections of clozapine (5 and 15 mg/kg), but not haloperidol (1 mg/kg), for 8 days decreased rat brain cortical dehydroepiandrosterone and dehydroepiandrosterone sulfate levels. These findings support the role of neurosteroids and possibly GABAA receptor modulation in the mechanism of action of clozapine.
AB - We examined the influence of the atypical antipsychotic agent clozapine compared to haloperidol, on levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate ester (both γ-aminobutyric acidA (GABAA) receptor allosteric antagonists) in the rat cortex. i.p. injections of clozapine (5 and 15 mg/kg), but not haloperidol (1 mg/kg), for 8 days decreased rat brain cortical dehydroepiandrosterone and dehydroepiandrosterone sulfate levels. These findings support the role of neurosteroids and possibly GABAA receptor modulation in the mechanism of action of clozapine.
KW - Clozapine
KW - Dehydroepiandosterone
KW - Dehydroepiandosterone sulphate
KW - Haloperidol
KW - Neurosteroids
KW - γ-Aminobutyric acid receptor
UR - http://www.scopus.com/inward/record.url?scp=0037212021&partnerID=8YFLogxK
U2 - 10.1016/S0924-977X(02)00077-9
DO - 10.1016/S0924-977X(02)00077-9
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AN - SCOPUS:0037212021
SN - 0924-977X
VL - 13
SP - 29
EP - 31
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 1
ER -