Closure of Long Surgical Incisions with Hemostatic Tissue Adhesive in a Porcine Skin Model

Ariel Neiman, Inbar Eshkol-Yogev, Aviad Keren, Maytal Foox, Oded Pinkas, Nyra Goldstein, Amos Gilhar, Meital Zilberman, Yehuda Ullmann

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

OBJECTIVE Skin adhesives offer many advantages over traditional wound-closure devices. Recently, the current research group reported on tissue adhesives composed of natural polymers (gelatin and alginate), which are biocompatible with mechanical properties suitable for tissue adhesion. The objective of the present study was to conduct clinical and histologic assessment of this hemostatic bioadhesive in the healing of long skin incisions (≥4 cm) in comparison with traditional and commercially available methods. METHODS Researchers created 24 long incisions on the ventral side of two domestic pigs to compare four different treatment modalities: two topical bioadhesives based on gelatin and alginate combined with the hemostatic agent kaolin, nylon sutures, and commercial tissue adhesive N-butyl-2-cyanoacrylate. The bioadhesive compounds were spread on the incision surface and then mixed either manually or with a double-headed syringe. After 14 days, clinical and histologic measurements were performed to evaluate the healing phase of the wounds. RESULTS The bioadhesive formulation that contained a relatively low crosslinker concentration demonstrated superior results to the formulation that contained a standard crosslinker concentration. However, no significant statistical differences were observed compared with the control incisions (sutures and commercial adhesive N-butyl-2-cyanoacrylate). This was verified by immunohistochemical analysis for epithelial integrity and scar formation as well as by clinical assessment. CONCLUSIONS This newly developed bioadhesive demonstrated suitable properties for the closure of long incisions in a porcine skin model.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalAdvances in Skin and Wound Care
Volume36
Issue number10
DOIs
StatePublished - 1 Oct 2023

Funding

FundersFunder number
Tel Aviv University

    Keywords

    • bioadhesive
    • cyanoacrylate
    • hydrogel
    • incision
    • kaolin
    • skin
    • suture
    • wound closure
    • wound healing

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