TY - JOUR
T1 - Closed loop insulin delivery in diabetes
AU - Battelino, Tadej
AU - Omladič, Jasna Šuput
AU - Phillip, Moshe
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The primary goal of type 1 diabetes treatment is attaining near-normal glucose values. This currently remains out of reach for most people with type 1 diabetes despite intensified insulin treatment in the form of insulin analogues, educational interventions, continuous glucose monitoring, and sensor augmented insulin pump. The main remaining problem is risk of hypoglycaemia, which cannot be sufficiently reduced in all patient groups. Additionally, patients' burn-out often develops with years of tedious day-to-day diabetes management, rendering available diabetes-related technology less efficient. Over the past 40 years, several attempts have been made towards computer-programmed insulin delivery in the form of closed loop, with faster developments especially in the past decade. Automated insulin delivery has reduced human error in glycaemic control and considerably lessened the burden of routine self-management. In this chapter, data from randomized controlled trials with closed-loop insulin delivery that included type 1 diabetes population are summarized, and an evidence-based vision for possible routine utilization of closed loop is provided.
AB - The primary goal of type 1 diabetes treatment is attaining near-normal glucose values. This currently remains out of reach for most people with type 1 diabetes despite intensified insulin treatment in the form of insulin analogues, educational interventions, continuous glucose monitoring, and sensor augmented insulin pump. The main remaining problem is risk of hypoglycaemia, which cannot be sufficiently reduced in all patient groups. Additionally, patients' burn-out often develops with years of tedious day-to-day diabetes management, rendering available diabetes-related technology less efficient. Over the past 40 years, several attempts have been made towards computer-programmed insulin delivery in the form of closed loop, with faster developments especially in the past decade. Automated insulin delivery has reduced human error in glycaemic control and considerably lessened the burden of routine self-management. In this chapter, data from randomized controlled trials with closed-loop insulin delivery that included type 1 diabetes population are summarized, and an evidence-based vision for possible routine utilization of closed loop is provided.
KW - artificial pancreas
KW - closed loop insulin delivery
KW - continuous glucose monitoring
KW - glucose variability
KW - glycaemic range
KW - hypoglycaemia
KW - mean blood glucose
KW - sensor augmented insulin pump
UR - http://www.scopus.com/inward/record.url?scp=84937514710&partnerID=8YFLogxK
U2 - 10.1016/j.beem.2015.03.001
DO - 10.1016/j.beem.2015.03.001
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C2 - 26051293
AN - SCOPUS:84937514710
VL - 29
SP - 315
EP - 325
JO - Best Practice and Research in Clinical Endocrinology and Metabolism
JF - Best Practice and Research in Clinical Endocrinology and Metabolism
SN - 1521-690X
IS - 3
ER -