TY - JOUR
T1 - Clopidogrel-induced systemic inflammatory response syndrome
AU - Wolf, Ido
AU - Mouallem, Meir
AU - Rath, Shmuel
AU - Farfel, Zvi
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Clopidogrel bisulfate, a widely used inhibitor of platelet aggregation, is considered at least as safe as aspirin. We describe a patient who developed a systemic inflammatory response syndrome consisting of high fever, tachycardia, cellulitis-like rash, impaired liver function, and mild leukopenia after receiving clopidogrel before coronary angiography and stent implantation. The reaction resolved promptly after withdrawal of the drug and recurred shortly after a rechallenge dose was administered, thus making the diagnosis of a clopidogrel-induced reaction highly probable. Recognition of this clopidogrel-induced syndrome is extremely important, both for rapid discontinuation of the offending drug and for avoidance of unnecessary drug therapy or invasive procedures.
AB - Clopidogrel bisulfate, a widely used inhibitor of platelet aggregation, is considered at least as safe as aspirin. We describe a patient who developed a systemic inflammatory response syndrome consisting of high fever, tachycardia, cellulitis-like rash, impaired liver function, and mild leukopenia after receiving clopidogrel before coronary angiography and stent implantation. The reaction resolved promptly after withdrawal of the drug and recurred shortly after a rechallenge dose was administered, thus making the diagnosis of a clopidogrel-induced reaction highly probable. Recognition of this clopidogrel-induced syndrome is extremely important, both for rapid discontinuation of the offending drug and for avoidance of unnecessary drug therapy or invasive procedures.
UR - http://www.scopus.com/inward/record.url?scp=0038407515&partnerID=8YFLogxK
U2 - 10.4065/78.5.618
DO - 10.4065/78.5.618
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AN - SCOPUS:0038407515
SN - 0025-6196
VL - 78
SP - 618
EP - 620
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 5
ER -