Cloning of the human brain GABA transporter

Hannah Nelson; Sreekala Mandiyan; Nathan Nelson

doi:10.1016/0014-5793(90)81149-I

Cloning of the human brain GABA transporter

Hannah Nelson, Sreekala Mandiyan, Nathan Nelson^*

^*Corresponding author for this work

Hoffmann-La Roche Inc.

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

A cDNA clone encoding a transporter for the neurotransmitter γ-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	FEBS Letters
Volume	269
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(90)81149-I
State	Published - 20 Aug 1990
Externally published	Yes

Keywords

Human
Neurotransmitter
Transport
cDNA, sequence
γ-Aminobutric acid

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10.1016/0014-5793(90)81149-I

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Cloning of the human brain GABA transporter

Abstract

Keywords

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