Cloning of the human brain GABA transporter

Hannah Nelson, Sreekala Mandiyan, Nathan Nelson

Research output: Contribution to journalArticlepeer-review

Abstract

A cDNA clone encoding a transporter for the neurotransmitter γ-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalFEBS Letters
Volume269
Issue number1
DOIs
StatePublished - 20 Aug 1990
Externally publishedYes

Keywords

  • Human
  • Neurotransmitter
  • Transport
  • cDNA, sequence
  • γ-Aminobutric acid

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