Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

Avi Orr-Urtreger; Michael F. Seldin; Antonio Baldini; Arthur L. Beaudet

doi:10.1016/0888-7543(95)80228-E

Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

Avi Orr-Urtreger, Michael F. Seldin, Antonio Baldini, Arthur L. Beaudet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

Original language	English
Pages (from-to)	399-402
Number of pages	4
Journal	Genomics
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(95)80228-E
State	Published - 20 Mar 1995
Externally published	Yes

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title = "Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor",

abstract = "We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.",

author = "Avi Orr-Urtreger and Seldin, {Michael F.} and Antonio Baldini and Beaudet, {Arthur L.}",

note = "Funding Information: We thank Dr. J. W. Patrick for providing the rat a7 cDNA and for valuable discussions. We also thank Drs. M. Nakao and J. Sutcliffe for providing the YAC contig of the Prader-Willi/Angelman region. This work was supported by NIH Grants HG00734 to M. F. Seldin and HG00210 to A. Baldini.",

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doi = "10.1016/0888-7543(95)80228-E",

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AU - Beaudet, Arthur L.

N1 - Funding Information: We thank Dr. J. W. Patrick for providing the rat a7 cDNA and for valuable discussions. We also thank Drs. M. Nakao and J. Sutcliffe for providing the YAC contig of the Prader-Willi/Angelman region. This work was supported by NIH Grants HG00734 to M. F. Seldin and HG00210 to A. Baldini.

PY - 1995/3/20

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N2 - We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

AB - We report the isolation of cDNA clones for the mouse α7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind α-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse α7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The α7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 ± 1.7 cM-Gas2-0.9 cM ± 0.9 cM-D7Mit70-1.8 ± 1.2 cM- Acra7-4.4 ± 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14.

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Cloning and mapping of the mouse α7-neuronal nicotinic acetylcholine receptor

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