Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition

Ronit Pinkas-Kramarski; Reuven Stein; Yitzhak Zimmer; Mordechai Sokolovsky

doi:10.1016/0014-5793(88)80911-6

Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition

Ronit Pinkas-Kramarski
, Reuven Stein
, Yitzhak Zimmer
, Mordechai Sokolovsky^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.

Original language	English
Pages (from-to)	174-178
Number of pages	5
Journal	FEBS Letters
Volume	239
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(88)80911-6
State	Published - 7 Nov 1988

Keywords

Muscarinic receptor
Phosphoinositide hydrolysis
Receptor ligand binding
Receptor subtype comparison

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10.1016/0014-5793(88)80911-6

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abstract = "Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.",

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AU - Pinkas-Kramarski, Ronit

AU - Stein, Reuven

AU - Zimmer, Yitzhak

AU - Sokolovsky, Mordechai

PY - 1988/11/7

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N2 - Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.

AB - Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.

KW - Muscarinic receptor

KW - Phosphoinositide hydrolysis

KW - Receptor ligand binding

KW - Receptor subtype comparison

UR - https://www.scopus.com/pages/publications/0023724820

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Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition

Abstract

Keywords

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