TY - JOUR
T1 - Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition
AU - Pinkas-Kramarski, Ronit
AU - Stein, Reuven
AU - Zimmer, Yitzhak
AU - Sokolovsky, Mordechai
PY - 1988/11/7
Y1 - 1988/11/7
N2 - Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.
AB - Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.
KW - Muscarinic receptor
KW - Phosphoinositide hydrolysis
KW - Receptor ligand binding
KW - Receptor subtype comparison
UR - http://www.scopus.com/inward/record.url?scp=0023724820&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(88)80911-6
DO - 10.1016/0014-5793(88)80911-6
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AN - SCOPUS:0023724820
SN - 0014-5793
VL - 239
SP - 174
EP - 178
JO - FEBS Letters
JF - FEBS Letters
IS - 2
ER -