Clomipramine-induced urinary dysfunction in an obsessive-compulsive adolescent

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Two episodes of urinary retention occurred in a 15-year-old male following administration of clomipromine given for obsessive-compulsive disorder. Improvement of behavioral symptoms along with side effects was clearly correlated with clomiparmine dosage. Severity of side effects, and their resistance to bethanechol and to phenoxybenzamine, necessitated a complete withdrawal of clomipramine. This case demonstrates that clomipramine-induced urinary retention is not limited to older individuals. Possible involvement of noncholinergic and nonadrenergic mechanisms in this adverse drug reaction is suggested.

Original languageEnglish
Pages (from-to)877-879
Number of pages3
JournalDrug Intelligence and Clinical Pharmacy
Issue number11
StatePublished - 1987
Externally publishedYes


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