Clinical, surgical, and histopathologic outcomes following failed medical abortion

Noga Fuchs*, Ron Maymon, Ido Ben-Ami, Sonia Mendlovic, David Schneider, Moty Pansky, Reuvit Halperin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: To address the consequences of surgical curettage following failed medical abortion. Methods: A retrospective case-control study was performed in a tertiary gynecologic department. The case group comprised 104 women who underwent surgical curettage following failed medical abortion; the control group included 104 women who underwent early surgically induced abortion. Clinical characteristics and surgical findings were examined. The extent of inflammation was quantified following immunohistochemical staining for cell-surface markers characteristic of T lymphocytes, B lymphocytes, and macrophages. The extent of necrosis was evaluated morphologically. Results: Abnormal findings during surgical curettage were significantly more prevalent among women in the case group than in the control group (10.6% versus 1.9%; P = 0.019). The most frequent abnormality in the case group was the presence of intimately adherent products of conception, necessitating sharp curettage. The extent of inflammation (represented by increased numbers of T and B lymphocytes) was greater in the case group than in the control group (P = 0.046 and P = 0.001, respectively), as was the extent of necrosis (P < 0.05). Conclusion: Curettage following failed medical abortion harbors particular difficulties, which may be attributed to an inflammatory response. The long-term consequences of curettage following failed medical abortion warrant further investigation.

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
StatePublished - Jun 2012


  • Failed medical abortion
  • Immunohistochemistry
  • Inflammation
  • Mifepristone
  • Necrosis
  • Surgical curettage


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