Clinical regression and remission of primary refractory angiocentric lymphoma following autologous tumour peptide antigen-charged dendritic cells after high-dose chemotherapy and autologous stem cell rescue

D. Taussig, M. A. Williams, C. Wiggins, R. M. Feakins, N. McBride, A. C. Newland, S. M. Kelsey

Research output: Contribution to journalArticlepeer-review

Abstract

We report on the case of a 34-year old man with a previously refractory high-grade non-Hodgkin's Lymphoma which regressed following dendritic cell based immunotherapy after high-dose chemotherapy. Antigen presenting cells known as dendritic cells were cultured from harvested autologous peripheral blood progenitor cells. The dendritic cells were then exposed to unfractionated tumour peptides derived from a skin biopsy section inflitrated with lymphoma. These charged dendritic cells infused into the patient together with autologous T-lymphocytes after high-dose chemotherapy with peripheral blood stem cell rescue. Although the lymphoma relapsed after the high-dose chemotherapy it regressed again following the dendritic cell infusion. The patient's T-lymphocytes demonstrated in vitro reactivity to tumour peptides whereas the lymphocytes of controls did not. We propose that the lymphoma regression occurred because of a T cell mediated response against the tumour induced by the charged dendritic cells.

Original languageEnglish
Pages (from-to)277-289
Number of pages13
JournalHematology
Volume3
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Angiocentric T-cell lymphoma
  • DC-dendritic cells
  • GM-CSF-granulocyte-macrophage colony-stimulating factor
  • High-dose chemotherapy
  • IL-2-interleukin-2
  • Immunotherapy
  • T-lymphocytes

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