TY - JOUR
T1 - Clinical predictors of Barrett's esophagus length
AU - Dickman, Ram
AU - Green, Colleen
AU - Chey, William D.
AU - Jones, Michael P.
AU - Eisen, Glenn M.
AU - Ramirez, Francisco
AU - Briseno, Michael
AU - Garewal, Harinder S.
AU - Fass, Ronnie
N1 - Funding Information:
This study was supported, in part, by a grant from the Investigator-Sponsored Trial Program of AstraZeneca.
PY - 2005/11
Y1 - 2005/11
N2 - Background: Assessment of clinical factors associated with Barrett's esophagus (BE) length remained within the realm of anecdotal reports or one center's experience. The aim of this multicenter study was to determine which clinical factors are highly correlated with the length of BE. Methods: Patients diagnosed with BE were recruited into the study from 5 academic centers in the United States. All patients had an upper endoscopy that documented BE by the presence of intestinal metaplasia in biopsy specimens. All patients were evaluated by a validated demographic questionnaire and the GERD Symptom Checklist. Results: A total of 263 patients with BE were recruited into the study. Mean BE length length for the entire sample was 4 ± 3.3 cm. A longer hiatal hernia (r = 0.22, p < 0.01), any dysplasia (t = -2.3, p < 0.05), H2 receptor antagonist (H2-RA) consumption (t = 1.98, p < 0.05), and nonsmoking (t = -2.5, p < 0.05) were correlated with a longer segment of BE. Proton pump inhibitors (PPI) (t = 1.96, p < 0.05) were correlated with a shorter segment of BE. Conclusions: PPIs were correlated with shorter lengths of BE. In contrast, a longer hiatal hernia, any dysplasia, nonsmoking, or use of H2-RAs were correlated with a longer BE segment.
AB - Background: Assessment of clinical factors associated with Barrett's esophagus (BE) length remained within the realm of anecdotal reports or one center's experience. The aim of this multicenter study was to determine which clinical factors are highly correlated with the length of BE. Methods: Patients diagnosed with BE were recruited into the study from 5 academic centers in the United States. All patients had an upper endoscopy that documented BE by the presence of intestinal metaplasia in biopsy specimens. All patients were evaluated by a validated demographic questionnaire and the GERD Symptom Checklist. Results: A total of 263 patients with BE were recruited into the study. Mean BE length length for the entire sample was 4 ± 3.3 cm. A longer hiatal hernia (r = 0.22, p < 0.01), any dysplasia (t = -2.3, p < 0.05), H2 receptor antagonist (H2-RA) consumption (t = 1.98, p < 0.05), and nonsmoking (t = -2.5, p < 0.05) were correlated with a longer segment of BE. Proton pump inhibitors (PPI) (t = 1.96, p < 0.05) were correlated with a shorter segment of BE. Conclusions: PPIs were correlated with shorter lengths of BE. In contrast, a longer hiatal hernia, any dysplasia, nonsmoking, or use of H2-RAs were correlated with a longer BE segment.
UR - http://www.scopus.com/inward/record.url?scp=27144441764&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2005.05.019
DO - 10.1016/j.gie.2005.05.019
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C2 - 16246678
AN - SCOPUS:27144441764
SN - 0016-5107
VL - 62
SP - 675
EP - 681
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
IS - 5
ER -