Clinical practice guidelines adaptation for internists - An EFIM methodology


Research output: Contribution to journalArticlepeer-review


The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with comorbid patients typically undergoing a polypharmacy. To help address this challenge, EFIM Clinical Practice Working Group started a project aimed to answer a series of relevant clinical questions, by selecting the best available guidance containing recommendations applicable to complex patients under polypharmacy. The project started with the creation of a research protocol containing details about all the steps needed to write the Clinical Practice Guideline Summary. In particular, this methodological document specifies the rules: 1) to select topics and clinical questions; 2) to build up a panel of experts, carefully managing eventual conflict of interests; 3) to critically appraise clinical guidelines (using a validated tool as AGREE II), selecting the most valid and applicable to the common clinical practice (using ADAPTE; 4) to address and solve potential disagreements among the selected documents.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEuropean Journal of Internal Medicine
StatePublished - Jul 2020


  • Clinical practice guidelines
  • Guideline adaptation
  • Internal medicine
  • Internists
  • Multimorbidity


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