Clinical pharmacology and therapeutic drug monitoring in neonates and children.

R. Loebstein*, G. Koren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


From a pharmacotherapy perspective, the process of development and growth represents an unstable and dynamic condition. Age-related changes in drug absorption, distribution, and metabolism among neonates, infants, and prepubescent children create a unique situation that may increase drug toxicity of some agents and protect from toxicity of other agents. Understanding the age-related changes in drug disposition that are relevant for therapeutic response and toxicity is essential for optimizing pharmacotherapy at different stages of childhood.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalPediatrics in Review
Issue number12
StatePublished - Dec 1998
Externally publishedYes


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