Clinical-pathological study of uterine leiomyomas with high mitotic activity

Ram Dgani*, Benjamin Piura, Gilad Ben-Baruch, Magda Open, Marek Glezerman, Dvora Nass, Bernard Czernobilsky, Ilana Yanai-Inbar, Uriel Elchalal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective. To evaluate clinical-pathological aspects of mitotically active leiomyomas. Study design. Twenty patients with smooth muscle tumors of the uterus, with 5-9 mitotic figures per 10 high power fields and without atypia or necrosis were studied. The clinical and pathological characteristics of these tumors were reviewed and analyzed. Results. Patients' ages ranged from 33 to 63 years (mean 42.5 years). The size of the tumors ranged from 1.5 to 9.5 cm (mean 5.4 cm). On gross examination all tumors appeared as typical leiomyomas. Treatment included hysterectomy in 16 patients and myomectomy in four. Follow-up periods ranged from 1.5 to 11 years (mean 6.8 years). None of the patients developed a recurrent tumor. Conclusion. The benign clinical behavior of such tumors supports their current designation as mitotically active leiomyomas, thus deleting the previous misnomer 'smooth muscle tumors of uncertain malignant potential'. Myomectomy is an appropriate treatment, particularly in young patients interested in reproduction.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number1
StatePublished - 1998
Externally publishedYes


  • Mitotically active leiomyoma


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