1. 1. Lithium is a unique drug in its clinical profile in psychiatry. 2. 2. Lithium has numerous biochemical effects, hut none has yet been proven to be its mode of therapeutic action. 3. 3. Inhibition of noradrenaline-sensitive adenylate cyclase is reviewed as the only biochemical effect of lithium shown to occur in both animals and man at therapeutic lithium concentrations. 4. 4. A tetracycline antibiotic, demeclocycline, also blocks noradrenaline-sensitive adenylate cyclase. 5. 5. A clinical trial of demeclocycline in mania would provide a test of the adenylate cyclase theory of lithium action.
|Number of pages||10|
|Journal||Progress in Neuro-Psychopharmacology and Biological Psychiatry|
|State||Published - 1983|
- adenylate cyclase
- antidiuretic hormone