TY - JOUR
T1 - Clinical impact of PET/MRI in oligometastatic colorectal cancer
AU - Furtado, Felipe S.
AU - Suarez-Weiss, Krista E.
AU - Vangel, Mark
AU - Clark, Jeffrey W.
AU - Cusack, James C.
AU - Hong, Theodore
AU - Blaszkowsky, Lawrence
AU - Wo, Jennifer
AU - Striar, Robin
AU - Umutlu, Lale
AU - Daldrup-Link, Heike E.
AU - Groshar, David
AU - Rocco, Ricciardi
AU - Bordeianou, Liliana
AU - Anderson, Mark A.
AU - Mojtahed, Amirkasra
AU - Qadan, Motaz
AU - Ferrone, Cristina
AU - Catalano, Onofrio A.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2021/9/28
Y1 - 2021/9/28
N2 - Background: Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies. Methods: This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a clinical impact on oligometastatic CRC relative to the standard of care imaging (SCI). Adult patients with oligometastatic CRC on SCI who also underwent PET/MR between 3/2016 and 3/2019 were included. The exclusion criterion was lack of confirmatory standard of reference, either surgical pathology, intraoperative gross confirmation or imaging follow-up. SCI consisted of contrast-enhanced (CE) computed tomography (CT) of the chest/abdomen/pelvis, abdominal/pelvic CE-MR, and/or CE whole-body PET/CT with diagnostic quality (i.e. standard radiation dose) CT. Follow-up was evaluated until 3/2020. Results: Thirty-one patients constituted the cohort, 16 (52%) male, median patient age was 53 years (interquartile range: 49–65 years). PET/MR and SCI results were divergent in 19% (95% CI 9–37%) of the cases, with PET/MR leading to management changes in all of them. The diagnostic accuracy of PET/MR was 90 ± 5%, versus 71 ± 8% for SCI. In a pairwise analysis, PET/MR outperformed SCI when compared to the reference standard (p = 0.0412). Conclusions: These findings suggest the potential usefulness of PET/MR in the management of oligometastatic CRC.
AB - Background: Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies. Methods: This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a clinical impact on oligometastatic CRC relative to the standard of care imaging (SCI). Adult patients with oligometastatic CRC on SCI who also underwent PET/MR between 3/2016 and 3/2019 were included. The exclusion criterion was lack of confirmatory standard of reference, either surgical pathology, intraoperative gross confirmation or imaging follow-up. SCI consisted of contrast-enhanced (CE) computed tomography (CT) of the chest/abdomen/pelvis, abdominal/pelvic CE-MR, and/or CE whole-body PET/CT with diagnostic quality (i.e. standard radiation dose) CT. Follow-up was evaluated until 3/2020. Results: Thirty-one patients constituted the cohort, 16 (52%) male, median patient age was 53 years (interquartile range: 49–65 years). PET/MR and SCI results were divergent in 19% (95% CI 9–37%) of the cases, with PET/MR leading to management changes in all of them. The diagnostic accuracy of PET/MR was 90 ± 5%, versus 71 ± 8% for SCI. In a pairwise analysis, PET/MR outperformed SCI when compared to the reference standard (p = 0.0412). Conclusions: These findings suggest the potential usefulness of PET/MR in the management of oligometastatic CRC.
UR - http://www.scopus.com/inward/record.url?scp=85110771404&partnerID=8YFLogxK
U2 - 10.1038/s41416-021-01494-8
DO - 10.1038/s41416-021-01494-8
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C2 - 34282295
AN - SCOPUS:85110771404
SN - 0007-0920
VL - 125
SP - 975
EP - 982
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 7
ER -
