Clinical Impact of β-Lactamase-producing Enterobacteriaceae in Sputum of Cystic Fibrosis Patients

Huda Mussaffi; Naama Fisch Shvalb; Haim Ben-Zvi; Gilat Livni; Meir Mei-Zahav; Dario Prais; Patrick Stafler; Guy Steuer; Hannah Blau

doi:10.1097/INF.0000000000000972

Clinical Impact of β-Lactamase-producing Enterobacteriaceae in Sputum of Cystic Fibrosis Patients

Huda Mussaffi, Naama Fisch Shvalb, Haim Ben-Zvi, Gilat Livni, Meir Mei-Zahav, Dario Prais, Patrick Stafler, Guy Steuer, Hannah Blau^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This case series describes 18 cystic fibrosis (CF) patients of a 135-patient CF center cohort with extended spectrum β-lactamase-producing Enterobacteriaceae, from 2003 to 2012. Four had chronic infection. Prevalence increased annually from 0 to 6.35%. Risk factors compared with the 2010 CF center cohort included continuous inhaled antibiotics (P = 0.014) and courses of intravenous antibiotics during the year before first isolation (P = 0.009). Hospitalization rates were 1.05/year and 0.47/year preinfection and postinfection, respectively (P = 0.02). Slope of forced expiratory volume at 1 second% predicted remained unchanged during 12 months.

Original language	English
Pages (from-to)	216-219
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	35
Issue number	2
DOIs	https://doi.org/10.1097/INF.0000000000000972
State	Published - 1 Feb 2016

Keywords

airway infection
cystic fibrosis
extended spectrum β-lactamase
producing Enterobacteriaceae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000000972

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title = "Clinical Impact of β-Lactamase-producing Enterobacteriaceae in Sputum of Cystic Fibrosis Patients",

abstract = "This case series describes 18 cystic fibrosis (CF) patients of a 135-patient CF center cohort with extended spectrum β-lactamase-producing Enterobacteriaceae, from 2003 to 2012. Four had chronic infection. Prevalence increased annually from 0 to 6.35%. Risk factors compared with the 2010 CF center cohort included continuous inhaled antibiotics (P = 0.014) and courses of intravenous antibiotics during the year before first isolation (P = 0.009). Hospitalization rates were 1.05/year and 0.47/year preinfection and postinfection, respectively (P = 0.02). Slope of forced expiratory volume at 1 second% predicted remained unchanged during 12 months.",

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AU - Ben-Zvi, Haim

AU - Livni, Gilat

AU - Mei-Zahav, Meir

AU - Prais, Dario

AU - Stafler, Patrick

AU - Steuer, Guy

AU - Blau, Hannah

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Clinical Impact of β-Lactamase-producing Enterobacteriaceae in Sputum of Cystic Fibrosis Patients

Abstract

Keywords

UN SDGs

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