Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel

Alexander Lowenthal; Hila Weisblum-Neuman; Einat Birk; Liat Ashkenazi-Hoffnung; Itzhak Levy; Haim Ben-Zvi; Gabriel Amir; Georgy Frenkel; Elchanan Bruckheimer; Havatzelet Yarden-Bilavsky; Dafna Marom; Eran Shostak; Elhanan Nahum; Tamir Dagan; Gabriel Chodick; Oded Scheuerman

doi:10.3201/eid2703.203022

Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel

Alexander Lowenthal, Hila Weisblum-Neuman, Einat Birk, Liat Ashkenazi-Hoffnung, Itzhak Levy, Haim Ben-Zvi, Gabriel Amir, Georgy Frenkel, Elchanan Bruckheimer, Havatzelet Yarden-Bilavsky, Dafna Marom, Eran Shostak, Elhanan Nahum, Tamir Dagan, Gabriel Chodick, Oded Scheuerman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Kingella spp. have emerged as an important cause of invasive pediatric diseases. Data on Kingella infective endocarditis (KIE) in children are scarce. We compared the clinical features of pediatric KIE cases with those of Streptococcus species IE (StIE) and Staphylococcus aureus IE (SaIE). A total of 60 patients were included in the study. Throughout the study period, a rise in incidence of KIE was noted. KIE patients were significantly younger than those with StIE and SaIE, were predominately boys, and had higher temperature at admission, history of oral aphthae before IE diagnosis, and higher lymphocyte count (p<0.05). Pediatric KIE exhibits unique features compared with StIE and SaIE. Therefore, in young healthy children <36 months of age, especially boys, with or without a congenital heart defect, with a recent history of oral aphthae, and experiencing signs and symptoms compatible with endocarditis, Kingella should be suspected as the causative pathogen.

Original language	English
Pages (from-to)	703-709
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	27
Issue number	3
DOIs	https://doi.org/10.3201/eid2703.203022
State	Published - Mar 2021

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Lowenthal, A., Weisblum-Neuman, H., Birk, E., Ashkenazi-Hoffnung, L., Levy, I., Ben-Zvi, H., Amir, G., Frenkel, G., Bruckheimer, E., Yarden-Bilavsky, H., Marom, D., Shostak, E., Nahum, E., Dagan, T., Chodick, G., & Scheuerman, O. (2021). Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel. Emerging Infectious Diseases, 27(3), 703-709. https://doi.org/10.3201/eid2703.203022

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title = "Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel",

abstract = "Kingella spp. have emerged as an important cause of invasive pediatric diseases. Data on Kingella infective endocarditis (KIE) in children are scarce. We compared the clinical features of pediatric KIE cases with those of Streptococcus species IE (StIE) and Staphylococcus aureus IE (SaIE). A total of 60 patients were included in the study. Throughout the study period, a rise in incidence of KIE was noted. KIE patients were significantly younger than those with StIE and SaIE, were predominately boys, and had higher temperature at admission, history of oral aphthae before IE diagnosis, and higher lymphocyte count (p<0.05). Pediatric KIE exhibits unique features compared with StIE and SaIE. Therefore, in young healthy children <36 months of age, especially boys, with or without a congenital heart defect, with a recent history of oral aphthae, and experiencing signs and symptoms compatible with endocarditis, Kingella should be suspected as the causative pathogen.",

author = "Alexander Lowenthal and Hila Weisblum-Neuman and Einat Birk and Liat Ashkenazi-Hoffnung and Itzhak Levy and Haim Ben-Zvi and Gabriel Amir and Georgy Frenkel and Elchanan Bruckheimer and Havatzelet Yarden-Bilavsky and Dafna Marom and Eran Shostak and Elhanan Nahum and Tamir Dagan and Gabriel Chodick and Oded Scheuerman",

year = "2021",

month = mar,

doi = "10.3201/eid2703.203022",

language = "אנגלית",

volume = "27",

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journal = "Emerging Infectious Diseases",

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Lowenthal, A, Weisblum-Neuman, H, Birk, E, Ashkenazi-Hoffnung, L , Levy, I, Ben-Zvi, H, Amir, G, Frenkel, G, Bruckheimer, E, Yarden-Bilavsky, H , Marom, D , Shostak, E , Nahum, E, Dagan, T, Chodick, G & Scheuerman, O 2021, 'Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel', Emerging Infectious Diseases, vol. 27, no. 3, pp. 703-709. https://doi.org/10.3201/eid2703.203022

TY - JOUR

T1 - Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel

AU - Lowenthal, Alexander

AU - Weisblum-Neuman, Hila

AU - Birk, Einat

AU - Ashkenazi-Hoffnung, Liat

AU - Levy, Itzhak

AU - Ben-Zvi, Haim

AU - Amir, Gabriel

AU - Frenkel, Georgy

AU - Bruckheimer, Elchanan

AU - Yarden-Bilavsky, Havatzelet

AU - Marom, Dafna

AU - Shostak, Eran

AU - Nahum, Elhanan

AU - Dagan, Tamir

AU - Chodick, Gabriel

AU - Scheuerman, Oded

PY - 2021/3

Y1 - 2021/3

N2 - Kingella spp. have emerged as an important cause of invasive pediatric diseases. Data on Kingella infective endocarditis (KIE) in children are scarce. We compared the clinical features of pediatric KIE cases with those of Streptococcus species IE (StIE) and Staphylococcus aureus IE (SaIE). A total of 60 patients were included in the study. Throughout the study period, a rise in incidence of KIE was noted. KIE patients were significantly younger than those with StIE and SaIE, were predominately boys, and had higher temperature at admission, history of oral aphthae before IE diagnosis, and higher lymphocyte count (p<0.05). Pediatric KIE exhibits unique features compared with StIE and SaIE. Therefore, in young healthy children <36 months of age, especially boys, with or without a congenital heart defect, with a recent history of oral aphthae, and experiencing signs and symptoms compatible with endocarditis, Kingella should be suspected as the causative pathogen.

AB - Kingella spp. have emerged as an important cause of invasive pediatric diseases. Data on Kingella infective endocarditis (KIE) in children are scarce. We compared the clinical features of pediatric KIE cases with those of Streptococcus species IE (StIE) and Staphylococcus aureus IE (SaIE). A total of 60 patients were included in the study. Throughout the study period, a rise in incidence of KIE was noted. KIE patients were significantly younger than those with StIE and SaIE, were predominately boys, and had higher temperature at admission, history of oral aphthae before IE diagnosis, and higher lymphocyte count (p<0.05). Pediatric KIE exhibits unique features compared with StIE and SaIE. Therefore, in young healthy children <36 months of age, especially boys, with or without a congenital heart defect, with a recent history of oral aphthae, and experiencing signs and symptoms compatible with endocarditis, Kingella should be suspected as the causative pathogen.

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Clinical features and comparison of kingella and non-kingella endocarditis in children, Israel

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