Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia

A. Amiel; S. Yarkoni; M. Fejgin; E. Gaber; A. Nagler; Y. Manor; M. Lishner

doi:10.1016/0165-4608(93)90055-Q

Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia

A. Amiel^*, S. Yarkoni, M. Fejgin, E. Gaber, A. Nagler, Y. Manor, M. Lishner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous leukemia (CML) after aggressive cytoreductive treatment. The analysis was made in interphase nuclei because of the very small number of recognizable metaphases in leukemic patients. FISH was a reliable tool for the detection of chromosome translocations in interphase nuclei as compared with conventional cytogenetic and polymerase chain reaction (PCR) techniques.

Original language	English
Pages (from-to)	32-34
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(93)90055-Q
State	Published - Jan 1993
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-4608(93)90055-Q

Cite this

@article{2cf03c2c1f0049b0845c04accbd454d4,

title = "Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia",

abstract = "We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous leukemia (CML) after aggressive cytoreductive treatment. The analysis was made in interphase nuclei because of the very small number of recognizable metaphases in leukemic patients. FISH was a reliable tool for the detection of chromosome translocations in interphase nuclei as compared with conventional cytogenetic and polymerase chain reaction (PCR) techniques.",

author = "A. Amiel and S. Yarkoni and M. Fejgin and E. Gaber and A. Nagler and Y. Manor and M. Lishner",

year = "1993",

month = jan,

doi = "10.1016/0165-4608(93)90055-Q",

language = "אנגלית",

volume = "65",

pages = "32--34",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia

AU - Amiel, A.

AU - Yarkoni, S.

AU - Fejgin, M.

AU - Gaber, E.

AU - Nagler, A.

AU - Manor, Y.

AU - Lishner, M.

PY - 1993/1

Y1 - 1993/1

N2 - We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous leukemia (CML) after aggressive cytoreductive treatment. The analysis was made in interphase nuclei because of the very small number of recognizable metaphases in leukemic patients. FISH was a reliable tool for the detection of chromosome translocations in interphase nuclei as compared with conventional cytogenetic and polymerase chain reaction (PCR) techniques.

AB - We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous leukemia (CML) after aggressive cytoreductive treatment. The analysis was made in interphase nuclei because of the very small number of recognizable metaphases in leukemic patients. FISH was a reliable tool for the detection of chromosome translocations in interphase nuclei as compared with conventional cytogenetic and polymerase chain reaction (PCR) techniques.

UR - http://www.scopus.com/inward/record.url?scp=0027477429&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(93)90055-Q

DO - 10.1016/0165-4608(93)90055-Q

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0027477429

SN - 0165-4608

VL - 65

SP - 32

EP - 34

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this