Clinical course and outcome of patients enrolled in US and non-US centres in MADIT-CRT

Jonathan Buber*, Helmut Klein, Arthur J. Moss, Scott McNitt, Michael Eldar, Luigi Padeletti, Juergen Vogt, Mathias Meine, Mary W. Brown, Alon Barsheshet, Wojciech Zareba, Ilan Goldenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aims We aimed to evaluate within the MADIT-CRT database whether different enrollment characteristics between US and non-US centres affected the clinical course of study patients. Methods and results We evaluated differences in baseline characteristics, procedure-associated complications, clinical as well as echocardiographic response to cardiac resynchronization therapy with a defibrillator (CRT-D), between patients enrolled in 87 US centres (n= 1271) and 23 non-US centres (n= 549) in MADIT-CRT. Non-US patients displayed significant differences in baseline characteristics from US patients, including a higher frequency of left bundle branch block, a more advanced heart failure (HF) functional class >3 months prior to enrolment, and larger baseline cardiac volumes. Procedure-related complications occurred at a significantly higher frequency among patients enrolled in non-US centres (17) than among those enrolled in US centres (10; P < 0.001). During follow-up, CRT-D was associated with 42 (P = 0.003) and 38 (P < 0.001) reductions in the risk of HF or death in the two respective groups (P for the difference = 0.80), and with similar reductions in cardiac volumes (all P > 0.10). Subgroup analysis showed a more pronounced effect of CRT-D among women in the US group, including a significant 71 (P = 0.02) reduction in the risk of death, whereas CRT-D therapy was associated with a significant clinical benefit in men only in the non-US group. Conclusion Patients enrolled in US and non-US centres in MADIT-CRT displayed significant differences in baseline clinical and echocardiographic characteristics and in the frequency of procedure-related complications, but experienced an overall similar clinical and echocardiographic response to CRT-D.

Original languageEnglish
Pages (from-to)2697-2704
Number of pages8
JournalEuropean Heart Journal
Issue number21
StatePublished - Nov 2011
Externally publishedYes


  • Cardiac resynchronization therapy
  • Complications
  • Death
  • Heart failure


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