Clinical characteristics of the West Nile fever outbreak, Israel, 2000

Michal Y. Chowers*, Ruth Lang, Faris Nassar, Debora Ben-David, Michael Giladi, Eitan Rubinshtein, Avi Itzhaki, Josef Mishal, Yardena Siegman-Igra, Ruth Kitzes, Neora Pick, Zvi Landau, Dana Wolf, Hanna Bin, Ella Mendelson, Silvio D. Pitlik, Miriam Weinberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


West Nile (WN) virus is endemic in Israel. The last reported outbreak had occurred in 1981. From August to October 2000, a large-scale epidemic of WN fever occurred in Israel; 417 cases were confirmed, with 326 hospitalizations. The main clinical presentations were encephalitis (57.9%), febrile disease (24,4%), and meningitis (15.9%). Within the study group, 33 (14.1%) hospitalized patients died. Mortality was higher among patients ≥70 years (29.3%). On multivariate regressional analysis, independent predictors of death were age ≥70 years (odds ratio [OR] 7.7), change in level of consciousness (OR 9.0), and anemia (OR 2.7). In contrast to prior reports, WN fever appears to be a severe illness with high rate of central nervous system involvement and a particularly grim outcome in the elderly.

Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalEmerging Infectious Diseases
Issue number4
StatePublished - 2001
Externally publishedYes


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