Clinical characteristics, and impairment and disability scale scores for different CIDP Disease Activity Status classes

Majed Alabdali, Alon Abraham, Abdulla Alsulaiman, Ari Breiner, Carolina Barnett, Hans D. Katzberg, Leif E. Lovblom, Bruce A. Perkins, Vera Bril*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction Selecting proper outcome measures is important for clinical practice and clinical studies assessing treatable neuropathies, such as chronic inflammatory demyelinating polyneuropathy (CIDP). Objectives To explore clinical characteristics and impairment and disability scores in CIDP patients, and assess their relationship to different CIDP Disease Activity Status (CDAS) classes. Methods We performed a retrospective chart review of CIDP patients attending the neuromuscular clinic between January 2014 and December 2015, and explored clinical characteristics, and various impairment and disability scores for different CDAS classes. Results The total cohort included 69 CIDP patients. A higher CDAS class was correlated with more frequent motor and sensory deficits, worse sensory sum score, worse scores on the disability scales, including the Rasch-built overall disability scale (RODS) and Overall Neuropathy Limitation Scale (ONLS), and lower treatment responsiveness. ONLS and RODS scales were significantly correlated (r = − 0.86, p < 0.0001). A change of one point or more in the ONLS score, was associated with a corresponding change of 4.1–4.5 points in the RODS score. Discussion The study results show that a higher CDAS class is correlated with a more severe neuropathy. This was reflected by the sensory sum score, RODS and ONLS. These results might help profile CIDP patients at different CDAS classes for clinical practice and future clinical studies.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalJournal of the Neurological Sciences
StatePublished - 15 Jan 2017
Externally publishedYes


  • CDAS
  • CIDP
  • MRC sum score
  • ONLS
  • RODS


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