Clinical application of static fluorescence-based cytometry, Cellscan, in cutaneous adverse drug reaction

Fares Salameh*, Martine Szyper Kravitz, Aviv Barzilai, Sharon Baum, Yehuda Shoenfeld, Yael Schiffenbauer, Ela Trubniykov, Henri Trau

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present study was to evaluate the effectiveness of Cellscan in identifying culprit drugs causing cutaneous adverse drug reaction. It was a prospective study with 3 months follow up conducted at the Departments of Dermatology, Internal Medicine and Dermatology Outpatient Clinic, Chaim Sheba Medical Center, Tel Hashomer, Israel. The study included 36 patients with cutaneous reaction suspected to be secondary to drugs, treated with a total number of 148 drugs. All patients and drugs were classified to three probability groups according to accepted clinical criteria. The effectiveness of the Cellscan test in identifying the culprit drug was addressed according to the clinical probability for cutaneous drug reaction, the drug class and the type of rash. Data analysis according to the clinical probability for cutaneous drug reaction revealed that patients in the moderate and high probability groups had a high test sensitivity of 77.7% and 83.3% with specificity of 71% and 63%, respectively, in identifying the culprit drug. Classifying the data according to drug classes, revealed that for the antibiotic and cardiovascular drug classes the sensitivity of the test was 100% and 92% with specificity of 83.3% and 55.5%, respectively, in identifying the culprit drug. Finally, the classification of patients according to the type of rash revealed a high evaluating accuracy for culprit drugs in maculopapular rashes with sensitivity and specificity of 90% and 60.4%, respectively. The results of this study imply that the Cellscan test is it a good practical tool for identifying the culprit drug in cutaneous adverse drug reaction.

Original languageEnglish
Pages (from-to)447-455
Number of pages9
JournalJournal of Dermatology
Volume38
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Cellscan
  • cutaneous adverse drug reaction
  • drug eruption
  • in vitro test
  • static fluorescence-based cytometry

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