A series of 183 gouty patients, 166 male and 17 female, was followed for from the months to 14 years. Of these, 138 were of European origin and 45 of Afro Asian origin. The average age at which the first attack of gouty arthritis appeared was 41.5 years in the males and 47.6 years in the females. Treatment consisted of uricosuric drugs in 129 patients, uricosuric drugs followed by allopurinol in 56, and allopurinol alone in 54. Allopurinol was more effective than uricosuric drugs in reducing the frequency of acute arthritis. Out of 14 patients with visible tophi who received uricosuric drugs, a tophus disappeared in one, but in none of eight patients with visible tophi treated with allopurinol was disappearance of tophi observed. Both drugs prevented the appearance of new tophi. Kidney function, as gauged by blood urea and creatinine clearance, did not improve following either of the drugs, but further decline in kidney function appeared to have been prevented. Side effects were observed in 18 patients on allopurinol (16.9%) and in 12 on uricosuric drugs (9.4%).
|State||Published - 1976|