Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Eli Magen; Sumit Mukherjee; Mahua Bhattacharya; Rajesh Detroja; Eugene Merzon; Idan Blum; Alejandro Livoff; Mark Shlapobersky; Gideon Baum; Ran Talisman; Evgenia Cherniavsky; Amir Dori; Milana Frenkel-Morgenstern

doi:10.3390/vaccines10071135

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Eli Magen^*, Sumit Mukherjee, Mahua Bhattacharya, Rajesh Detroja, Eugene Merzon, Idan Blum, Alejandro Livoff, Mark Shlapobersky, Gideon Baum, Ran Talisman, Evgenia Cherniavsky, Amir Dori, Milana Frenkel-Morgenstern^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

Original language	English
Article number	1135
Journal	Vaccines
Volume	10
Issue number	7
DOIs	https://doi.org/10.3390/vaccines10071135
State	Published - Jul 2022

Funding

Funders	Funder number
COVID-19 Data Science Institute
Israeli Council of Higher Education and Research
Bar-Ilan University	247017
Defence Science Institute

Keywords

BNT162b2
COVID-19
mRNA vaccine
myositis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/vaccines10071135

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Magen, E., Mukherjee, S., Bhattacharya, M., Detroja, R., Merzon, E., Blum, I., Livoff, A., Shlapobersky, M., Baum, G., Talisman, R., Cherniavsky, E., Dori, A., & Frenkel-Morgenstern, M. (2022). Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis. Vaccines, 10(7), Article 1135. https://doi.org/10.3390/vaccines10071135

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Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

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