@article{974d00d7a1b4470caefbb359273778b6,
title = "Clinical and Laboratory Features in the Israeli Population with COVID-19 Infection after Pfizer-BioNTech mRNA Booster Vaccination",
abstract = "Background: Immune protection following either vaccination or infection with SARS-CoV-2 decreases over time. Objective: We aim to describe clinical and sociodemographic characteristics associated with COVID-19 infection at least 14 days after booster vaccination in the Israeli population. Methods: We conducted a population-based study among adult members of Leumit Health Services (LHS) in Israel. Nasopharyngeal swabs were examined for SARS-CoV-2 by real-time RT-PCR. The hematological and biochemical parameters in the peripheral blood before booster vaccination were evaluated. Results: Between 1 February 2021 and 30 November 2021, 136,683 individuals in LHS were vaccinated with a booster (third dose) of the BNT162b2 vaccine. Of these, 1171 (0.9%) were diagnosed with COVID-19 by testing positive for SARS-CoV-2 RT-PCR at least >14 days after the booster vaccination. The COVID-19-positive group was characterized by higher rates of chronic kidney disease than the matched COVID-19-negative group (43 (3.7%) vs. 3646 (2.7%); p = 0.039). Anemia, lower peripheral blood lymphocytes, monocytes, basophils, C3 Complement, cholesterol, and prothrombin time were also associated with COVID-19 after booster vaccination. Conclusion: People with chronic kidney disease and anemia should be included in possible future annual SARS-CoV-2 vaccination recommendations.",
keywords = "BNT162b2, SARS-CoV-2, convalescents, infection, mRNA, vaccine",
author = "Ariel Israel and Eugene Merzon and Yotam Shenhar and Ilan Green and Avivit Golan-Cohen and Sch{\"a}ffer, {Alejandro A.} and Eytan Ruppin and Shlomo Vinker and Eli Magen",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = may,
doi = "10.3390/vaccines10050636",
language = "אנגלית",
volume = "10",
journal = "Vaccines",
issn = "2076-393X",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "5",
}