TY - JOUR
T1 - Clinical and epidemiological significance of carbapenem resistance in Acinetobacter baumannii infections
AU - Tal-Jasper, Ruthy
AU - Katz, David E.
AU - Amrami, Nadav
AU - Ravid, Dor
AU - Avivi, Dori
AU - Zaidenstein, Ronit
AU - Lazarovitch, Tsilia
AU - Dadon, Mor
AU - Kaye, Keith S.
AU - Marchaim, Dror
N1 - Publisher Copyright:
Copyright © 2016, American Society for Microbiology. All Rights Reserved.
PY - 2016/5
Y1 - 2016/5
N2 - Carbapenems are considered the treatment of choice for Acinetobacter baumannii infections. Many facilities implement preventive measures toward only carbapenem-resistant A. baumannii (CRAB). However, the independent role of the carbapenem resistance determinant on patient outcomes remains controversial. In a 6-year analysis of adults with A. baumannii bloodstream infection (BSI), the outcomes of 149 CRAB isolates were compared to those of 91 patients with carbapenem-susceptible A. baumannii. In bivariable analyses, CRAB BSIs were significantly associated with worse outcomes and with a delay in the initiation of appropriate antimicrobial therapy (DAAT). However, in multivariable analyses, carbapenem resistance status was no longer associated with poor outcomes, while DAAT remained an independent predictor. The epidemiological significance of A. baumannii should not be determined by its resistance to carbapenems.
AB - Carbapenems are considered the treatment of choice for Acinetobacter baumannii infections. Many facilities implement preventive measures toward only carbapenem-resistant A. baumannii (CRAB). However, the independent role of the carbapenem resistance determinant on patient outcomes remains controversial. In a 6-year analysis of adults with A. baumannii bloodstream infection (BSI), the outcomes of 149 CRAB isolates were compared to those of 91 patients with carbapenem-susceptible A. baumannii. In bivariable analyses, CRAB BSIs were significantly associated with worse outcomes and with a delay in the initiation of appropriate antimicrobial therapy (DAAT). However, in multivariable analyses, carbapenem resistance status was no longer associated with poor outcomes, while DAAT remained an independent predictor. The epidemiological significance of A. baumannii should not be determined by its resistance to carbapenems.
UR - http://www.scopus.com/inward/record.url?scp=84964822223&partnerID=8YFLogxK
U2 - 10.1128/AAC.02656-15
DO - 10.1128/AAC.02656-15
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C2 - 26883694
AN - SCOPUS:84964822223
SN - 0066-4804
VL - 60
SP - 3127
EP - 3131
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 5
ER -
