Clinical and economic analysis of rescue intracytoplasmic sperm injection cycles

Einat Shalom-Paz, Jana Alshalati, Fady Shehata, Luis Jimenez, Weon Young Son, Hananel Holzer, Seang Lin Tan, Benny Almog

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To identify clinical and embryological factors that may predict success in rescue intracytoplasmic sperm injection (ICSI) cycles (after total fertilization failure has occurred) and to evaluate the cost effectiveness of rescue ICSI strategy. Additionally, follow-up of 20 rescue ICSI pregnancies is reported. Design. Retrospective analysis of total fertilization failure cycles. Setting. University-based tertiary medical center. Material and methods. In total, 92 patients who had undergone conventional in-vitro fertilization (IVF) cycles with total fertilization failure were included. The patients were divided into two subgroups: those who conceived through rescue ICSI and those who did not. Results. The pregnant members of the rescue ICSI subgroup were found to be significantly younger (32.9 ± 4.2 vs. 36.3 ± 4.5, respectively, p = 0.0035,) and to have better-quality embryos than those who did not conceive (cumulative embryo score: 38.3 ± 20.4 vs. 29.3 ± 14.7, p = 0.025). Cost effectiveness analysis showed 25% reduction in the cost per live birth when rescue ICSI is compared to cycle cancellation approach. The pregnancies follow-up did not show adverse perinatal outcome. Conclusions. Rescue ICSI is an option for salvaging IVF cycles complicated by total fertilization failure. Success in rescue ICSI was found to be associated with younger age and higher quality of embryos. Furthermore, the cost effectiveness of rescue ICSI in terms of total fertilization failure was found to be worthwhile.

Original languageEnglish
Pages (from-to)993-996
Number of pages4
JournalGynecological Endocrinology
Volume27
Issue number12
DOIs
StatePublished - Dec 2011
Externally publishedYes

Keywords

  • delivery rate
  • economic analysis
  • Rescue ICSI

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