Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species

A. Rudi, T. Yosief, S. Loya, A. Hizi, M. Schleyer, Y. Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

As part of a search for novel inhibitors of humandeficiency virus type 1 (HIV-1) reverse transcriptase (RT), the MeOH-EtOAc extract of a Red Sea sponge, Clathria sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, clathsterol (1), which is responsible for the activity and is active at a concentration of 10 μM. The structure of 1 was established mainly by interpretation of spectral data and a chemical transformation.

Original languageEnglish
Pages (from-to)1451-1453
Number of pages3
JournalJournal of Natural Products
Volume64
Issue number11
DOIs
StatePublished - 2001

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