Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species

A. Rudi; T. Yosief; S. Loya; A. Hizi; M. Schleyer; Y. Kashman

doi:10.1021/np010121s

Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species

A. Rudi, T. Yosief, S. Loya, A. Hizi, M. Schleyer, Y. Kashman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

As part of a search for novel inhibitors of humandeficiency virus type 1 (HIV-1) reverse transcriptase (RT), the MeOH-EtOAc extract of a Red Sea sponge, Clathria sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, clathsterol (1), which is responsible for the activity and is active at a concentration of 10 μM. The structure of 1 was established mainly by interpretation of spectral data and a chemical transformation.

Original language	English
Pages (from-to)	1451-1453
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	11
DOIs	https://doi.org/10.1021/np010121s
State	Published - 2001

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10.1021/np010121s

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abstract = "As part of a search for novel inhibitors of humandeficiency virus type 1 (HIV-1) reverse transcriptase (RT), the MeOH-EtOAc extract of a Red Sea sponge, Clathria sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, clathsterol (1), which is responsible for the activity and is active at a concentration of 10 μM. The structure of 1 was established mainly by interpretation of spectral data and a chemical transformation.",

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AU - Schleyer, M.

AU - Kashman, Y.

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Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species

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