Classification of HHV-6A and HHV-6B as distinct viruses

Dharam Ablashi; Henri Agut; Roberto Alvarez-Lafuente; Duncan A. Clark; Stephen Dewhurst; Dario DiLuca; Louis Flamand; Niza Frenkel; Robert Gallo; Ursula A. Gompels; Per Höllsberg; Steven Jacobson; Mario Luppi; Paolo Lusso; Mauro Malnati; Peter Medveczky; Yasuko Mori; Philip E. Pellett; Joshua C. Pritchett; Koichi Yamanishi; Tetsushi Yoshikawa

doi:10.1007/s00705-013-1902-5

Classification of HHV-6A and HHV-6B as distinct viruses

Dharam Ablashi^*
, Henri Agut
, Roberto Alvarez-Lafuente
, Duncan A. Clark
, Stephen Dewhurst
, Dario DiLuca
, Louis Flamand
, Niza Frenkel
, Robert Gallo
, Ursula A. Gompels
, Per Höllsberg
, Steven Jacobson
, Mario Luppi
, Paolo Lusso
, Mauro Malnati
, Peter Medveczky
, Yasuko Mori
, Philip E. Pellett
, Joshua C. Pritchett
, Koichi Yamanishi

Tetsushi Yoshikawa

^*Corresponding author for this work

Department of Cell Research and Immunology

Research output: Contribution to journal › Review article › peer-review

297 Scopus citations

Abstract

Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

Original language	English
Pages (from-to)	863-870
Number of pages	8
Journal	Archives of Virology
Volume	159
Issue number	5
DOIs	https://doi.org/10.1007/s00705-013-1902-5
State	Published - May 2014

Funding

Funders	Funder number
National Institute of Neurological Disorders and Stroke	ZIANS002817

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Ablashi, D., Agut, H., Alvarez-Lafuente, R., Clark, D. A., Dewhurst, S., DiLuca, D., Flamand, L., Frenkel, N., Gallo, R., Gompels, U. A., Höllsberg, P., Jacobson, S., Luppi, M., Lusso, P., Malnati, M., Medveczky, P., Mori, Y., Pellett, P. E., Pritchett, J. C., ... Yoshikawa, T. (2014). Classification of HHV-6A and HHV-6B as distinct viruses. Archives of Virology, 159(5), 863-870. https://doi.org/10.1007/s00705-013-1902-5

@article{19a76bab53c941c49c15543073bd587b,

title = "Classification of HHV-6A and HHV-6B as distinct viruses",

abstract = "Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.",

author = "Dharam Ablashi and Henri Agut and Roberto Alvarez-Lafuente and Clark, \{Duncan A.\} and Stephen Dewhurst and Dario DiLuca and Louis Flamand and Niza Frenkel and Robert Gallo and Gompels, \{Ursula A.\} and Per H{\"o}llsberg and Steven Jacobson and Mario Luppi and Paolo Lusso and Mauro Malnati and Peter Medveczky and Yasuko Mori and Pellett, \{Philip E.\} and Pritchett, \{Joshua C.\} and Koichi Yamanishi and Tetsushi Yoshikawa",

year = "2014",

month = may,

doi = "10.1007/s00705-013-1902-5",

language = "אנגלית",

volume = "159",

pages = "863--870",

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Ablashi, D, Agut, H, Alvarez-Lafuente, R, Clark, DA, Dewhurst, S, DiLuca, D, Flamand, L, Frenkel, N, Gallo, R, Gompels, UA, Höllsberg, P, Jacobson, S, Luppi, M, Lusso, P, Malnati, M, Medveczky, P, Mori, Y, Pellett, PE, Pritchett, JC, Yamanishi, K & Yoshikawa, T 2014, 'Classification of HHV-6A and HHV-6B as distinct viruses', Archives of Virology, vol. 159, no. 5, pp. 863-870. https://doi.org/10.1007/s00705-013-1902-5

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AU - Ablashi, Dharam

AU - Agut, Henri

AU - Alvarez-Lafuente, Roberto

AU - Clark, Duncan A.

AU - Dewhurst, Stephen

AU - DiLuca, Dario

AU - Flamand, Louis

AU - Frenkel, Niza

AU - Gallo, Robert

AU - Gompels, Ursula A.

AU - Höllsberg, Per

AU - Jacobson, Steven

AU - Luppi, Mario

AU - Lusso, Paolo

AU - Malnati, Mauro

AU - Medveczky, Peter

AU - Mori, Yasuko

AU - Pellett, Philip E.

AU - Pritchett, Joshua C.

AU - Yamanishi, Koichi

AU - Yoshikawa, Tetsushi

PY - 2014/5

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AB - Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

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Classification of HHV-6A and HHV-6B as distinct viruses

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