Class II HLA-DC β-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis

D. Cohen, O. Cohen, A. Marcadet, C. Massart, M. Lathrop, I. Deschamps, J. Hors, E. Schuller, J. Dausset

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with a β-chain HLA-DC cDNA probe was found to be strongly correlated with HLA-DR2 in the normal population, but was absent in HLA-DR2 insulin-dependent diabetic patients. This fragment was found in HLA-DR2 multiple sclerosis patients with the same frequency as in controls. A β-chain HLA-DC 12-kilobase-pair BamHI fragment might differentiate multiple sclerosis patients from healthy individuals.

Original languageEnglish
Pages (from-to)1774-1778
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number6 I
DOIs
StatePublished - 1984
Externally publishedYes

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