TY - JOUR
T1 - Class II HLA-DC β-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis
AU - Cohen, D.
AU - Cohen, O.
AU - Marcadet, A.
AU - Massart, C.
AU - Lathrop, M.
AU - Deschamps, I.
AU - Hors, J.
AU - Schuller, E.
AU - Dausset, J.
PY - 1984
Y1 - 1984
N2 - HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with a β-chain HLA-DC cDNA probe was found to be strongly correlated with HLA-DR2 in the normal population, but was absent in HLA-DR2 insulin-dependent diabetic patients. This fragment was found in HLA-DR2 multiple sclerosis patients with the same frequency as in controls. A β-chain HLA-DC 12-kilobase-pair BamHI fragment might differentiate multiple sclerosis patients from healthy individuals.
AB - HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with a β-chain HLA-DC cDNA probe was found to be strongly correlated with HLA-DR2 in the normal population, but was absent in HLA-DR2 insulin-dependent diabetic patients. This fragment was found in HLA-DR2 multiple sclerosis patients with the same frequency as in controls. A β-chain HLA-DC 12-kilobase-pair BamHI fragment might differentiate multiple sclerosis patients from healthy individuals.
UR - http://www.scopus.com/inward/record.url?scp=0021341456&partnerID=8YFLogxK
U2 - 10.1073/pnas.81.6.1774
DO - 10.1073/pnas.81.6.1774
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AN - SCOPUS:0021341456
SN - 0027-8424
VL - 81
SP - 1774
EP - 1778
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 6 I
ER -