Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: Presumptive evidence for an interaction between vitamins C and E in vivo

Dror Harats, Shlomit Chevion, Menahem Nahir, Yehudit Norman, Oded Sagee, Elliot M. Berry

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the effects of vitamin C on cardiovascular risk factors, we studied dietary vitamin C enrichment in 36 healthy male students consuming a diet high in saturated fatty acids. After a 1-mo run-in period during which the subjects consumed ≃50 mg ascorbic acid/d (low-C diet), half of the subjects were randomly assigned to receive 500 mg ascorbic acid/d for an additional 2 mo (high-C diet). Plasma ascorbic acid increased from 13.5 μmol/L with the low-C diet to 51.7 μmol/L with the high-C diet. Plasma cholesterol increased slightly with the high-C diet, but not above baseline concentrations. This increase was offset by an increase in the lag period of in vitro LDL oxidation, which correlated with plasma ascorbic acid concentrations (r = 0.735, P = 0.0012). Lipoprotein vitamin E concentrations were unchanged with the two diets. There were no effects on concentrations of fibrinogen or factor VII. The fact that ascorbic acid reduced the in vitro susceptibility of lipoproteins to oxidation provides presumptive evidence for an interaction between aqueous and lipophilic antioxidants (vitamins C and E) in maintaining the integrity of LDL particles.

Original languageEnglish
Pages (from-to)240-245
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume67
Issue number2
DOIs
StatePublished - 1998

Keywords

  • Antioxidant
  • Ascorbic acid
  • Cardiovascular risk
  • Citrus fruit
  • Fibrinogen
  • Lipoprotein oxidation
  • Low-density lipoprotein
  • Men
  • Vitamin C
  • Vitamin E

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