Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer

Erez Shmuel Davidi; Tamar Dreifuss; Menachem Motiei; Eliezer Shai; Dimitri Bragilovski; Leon Lubimov; Marc Jose Jonathan Kindler; Aron Popovtzer; Jeremy Don; Rachela Popovtzer

doi:10.1002/hed.24935

Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer

Erez Shmuel Davidi, Tamar Dreifuss, Menachem Motiei, Eliezer Shai, Dimitri Bragilovski, Leon Lubimov, Marc Jose Jonathan Kindler, Aron Popovtzer, Jeremy Don, Rachela Popovtzer^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Background: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. Results: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. Conclusion: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.

Original language	English
Pages (from-to)	70-78
Number of pages	9
Journal	Head and Neck
Volume	40
Issue number	1
DOIs	https://doi.org/10.1002/hed.24935
State	Published - Jan 2018

Keywords

CT
cancer
cisplatin
gold nanoparticles
radiotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.24935

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title = "Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer",

abstract = "Background: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. Results: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. Conclusion: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.",

keywords = "CT, cancer, cisplatin, gold nanoparticles, radiotherapy",

author = "Davidi, {Erez Shmuel} and Tamar Dreifuss and Menachem Motiei and Eliezer Shai and Dimitri Bragilovski and Leon Lubimov and Kindler, {Marc Jose Jonathan} and Aron Popovtzer and Jeremy Don and Rachela Popovtzer",

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year = "2018",

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doi = "10.1002/hed.24935",

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T1 - Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer

AU - Davidi, Erez Shmuel

AU - Dreifuss, Tamar

AU - Motiei, Menachem

AU - Shai, Eliezer

AU - Bragilovski, Dimitri

AU - Lubimov, Leon

AU - Kindler, Marc Jose Jonathan

AU - Popovtzer, Aron

AU - Don, Jeremy

AU - Popovtzer, Rachela

PY - 2018/1

Y1 - 2018/1

N2 - Background: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. Results: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. Conclusion: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.

AB - Background: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. Results: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. Conclusion: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.

KW - CT

KW - cancer

KW - cisplatin

KW - gold nanoparticles

KW - radiotherapy

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SN - 1043-3074

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EP - 78

JO - Head and Neck

JF - Head and Neck

IS - 1

ER -

Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer

Abstract

Keywords

UN SDGs

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