Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis

Lior Goldberg, Tal Tirosh-Wagner, Amir Vardi, Haya Abbas, Nir Pillar, Noam Shomron, Yael Nevo-Caspi, Gideon Paret

Research output: Contribution to journalArticlepeer-review

Abstract

Viral myocarditis (VM) can be a life-threatening event resulting in cardiac failure, chronic cardiomyopathy, and death. VM typically includes three phases, i.e., acute, subacute, and resolution/chronic. We prospectively investigated cardiac- and inflammatory-associated plasma-circulating miRNA levels in eight pediatric patients with VM during the three stages of the disease. The level of cardiac-associated miR-208a was significantly elevated during the acute phase compared with the subacute and resolution/chronic phases. The level of cardiac- and inflammatory-associated miR-21 was significantly elevated during the acute phase compared to the resolution/chronic phase. Moreover, cardiac-associated miR-208b levels during the subacute phase correlated with systolic left ventricular function recovery as measured during the resolution/chronic phase. The findings of our study demonstrate an association between cardiac damage and the inflammatory response and the expression of miR-208a and miR-21 during the pathological progression of myocarditis. We also found that miR-208b levels exhibit a prognostic significance for left ventricular functional recovery.

Original languageEnglish
Pages (from-to)319-328
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume11
Issue number4
DOIs
StatePublished - 1 Aug 2018

Keywords

  • Circulating microRNA
  • Inflammation
  • Shortening fraction
  • Viral myocarditis

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