TY - JOUR
T1 - Circulating autoimmune antibodies may be responsible for implantation failure in in vitro fertilization
AU - Geva, E.
AU - Yaron, Y.
AU - Lessing, J. B.
AU - Yovel, I.
AU - Vardinon, N.
AU - Burke, M.
AU - Amit, A.
PY - 1994
Y1 - 1994
N2 - Objective: To investigate the role of autoimmune factors as a possible cause for implantation failure as manifested by chemical pregnancy after IVF and ET. Design: Anticardiolipin, anti-double-stranded DNA (dsDNA), antinuclear antibody, lupus anticoagulant, and rheumatoid factor serum levels were examined in patients with chemical pregnancies and in matched controls. Setting: An IVF unit, university-based IVF program. Patients: The study group included 21 patients who had had one or more chemical pregnancies and no deliveries. The control group consisted of 21 patients who had conceived and delivered after IVF-ET treatment, without any history of fetal wastage, matched for age, type and duration of infertility, and number of previous IVF cycles. Results: The incidence of circulating autoimmune antibodies in the study group was 33.3% (7/21). Three patients (14.2%) were positive for anticardiolipin, two (9.5%) were positive for anti-dsDNA, one (4.7%) for antinuclear factor, and one (4.7%) for rheumatoid factor. Autoimmune antibodies were not detected in any of the control group. Conclusion: Autoimmunity may play a role in implantation failure in IVF-ET. Circulating autoimmune antibody screening is therefore recommended after chemical pregnancy.
AB - Objective: To investigate the role of autoimmune factors as a possible cause for implantation failure as manifested by chemical pregnancy after IVF and ET. Design: Anticardiolipin, anti-double-stranded DNA (dsDNA), antinuclear antibody, lupus anticoagulant, and rheumatoid factor serum levels were examined in patients with chemical pregnancies and in matched controls. Setting: An IVF unit, university-based IVF program. Patients: The study group included 21 patients who had had one or more chemical pregnancies and no deliveries. The control group consisted of 21 patients who had conceived and delivered after IVF-ET treatment, without any history of fetal wastage, matched for age, type and duration of infertility, and number of previous IVF cycles. Results: The incidence of circulating autoimmune antibodies in the study group was 33.3% (7/21). Three patients (14.2%) were positive for anticardiolipin, two (9.5%) were positive for anti-dsDNA, one (4.7%) for antinuclear factor, and one (4.7%) for rheumatoid factor. Autoimmune antibodies were not detected in any of the control group. Conclusion: Autoimmunity may play a role in implantation failure in IVF-ET. Circulating autoimmune antibody screening is therefore recommended after chemical pregnancy.
KW - IVF-ET
KW - anticardiolipin
KW - autoantibodies
KW - autoimmune disease
KW - chemical pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0028101809&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)57008-3
DO - 10.1016/S0015-0282(16)57008-3
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AN - SCOPUS:0028101809
SN - 0015-0282
VL - 62
SP - 802
EP - 806
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4
ER -