Circulating and Synovial Monocytes in Arthritis and Ex-Vivo Model to Evaluate Therapeutic Modulation of Synovial Monocytes

Adam Slavick, Victoria Furer, Ari Polachek, Reut Tzemach, Ori Elkayam, Smadar Gertel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Monocytes are innate immune cells that play a dual role in protection of host against pathogens and initiation and perpetuation of inflammatory disorders including joint diseases. During inflammation, monocytes migrate from peripheral blood to tissues via chemokine receptors where they produce inflammatory factors. Monocytes are classified into three subsets, namely: classical, intermediate and non-classical, each subset has particular function. Synovium of patients with inflammatory joint diseases, such as rheumatoid arthritis and psoriatic arthritis as well as osteoarthritis, is enriched by monocytes that differ from circulatory ones by distinct subsets distribution. Several therapeutic agents used systemically or locally through intra-articular injections in arthritis management modulate monocyte subsets. This scoping review summarized the existing literature delineating the effect of common therapeutic agents used in arthritis management on circulating and synovial monocytes/macrophages. As certain agents have an inhibitory effect on monocytes, we propose to test their potential to inhibit synovial monocytes via an ex-vivo platform based on cultured synovial fluid mononuclear cells derived from patients with rheumatic diseases. Information obtained from the ex-vivo platform can be applied to explore the therapeutic potential of medications in clinical practice.

Original languageEnglish
Pages (from-to)832-855
Number of pages24
JournalImmunological Investigations
Issue number7
StatePublished - 2023


FundersFunder number
American Medical Program at Sackler Faculty of Medicine, Tel Aviv University


    • Anti-rheumatic drugs
    • monocytes
    • osteoarthritis
    • psoriatic arthritis
    • rheumatoid arthritis


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