Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

Franz Hefti; Eldad Melamed; Barbara J. Sahakian; Richard J. Wurtman

doi:10.1016/0091-3057(80)90353-6

Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

Franz Hefti, Eldad Melamed, Barbara J. Sahakian, Richard J. Wurtman

Research output: Contribution to journal › Article › peer-review

Abstract

Partial, unilateral lesions of the nigro-striatal tract were produced in rats by injecting various quantities of 6-hydroxydopamine into the substantia nigra. The extent of each animal's lesion was estimated by comparing tyrosine hydroxylase activities in its lesioned and control striata. L-DOPA and apomorphine induced contralateral (i.e., away from the lesion) circling behavior only in rats in which more than 90% of the nigro-striatal system had been destroyed. In contrast, d-amphetamine caused turning in the ipsilateral direction when as few as 50% of the nigro-striatal neurons had been destroyed.

Original language	English
Pages (from-to)	185-188
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(80)90353-6
State	Published - Feb 1980
Externally published	Yes

Keywords

6-Hydroxydopamine
Amphetamine
Apomorphine
Circling behavior
DOPA
Dopamine
Nigro-striatal neurons
Rats

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10.1016/0091-3057(80)90353-6

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title = "Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA",

abstract = "Partial, unilateral lesions of the nigro-striatal tract were produced in rats by injecting various quantities of 6-hydroxydopamine into the substantia nigra. The extent of each animal's lesion was estimated by comparing tyrosine hydroxylase activities in its lesioned and control striata. L-DOPA and apomorphine induced contralateral (i.e., away from the lesion) circling behavior only in rats in which more than 90% of the nigro-striatal system had been destroyed. In contrast, d-amphetamine caused turning in the ipsilateral direction when as few as 50% of the nigro-striatal neurons had been destroyed.",

keywords = "6-Hydroxydopamine, Amphetamine, Apomorphine, Circling behavior, DOPA, Dopamine, Nigro-striatal neurons, Rats",

author = "Franz Hefti and Eldad Melamed and Sahakian, {Barbara J.} and Wurtman, {Richard J.}",

note = "Funding Information: This study was supported in part by the National Institutes of Health and the American Parkinson's Disease Association. F. H. was supported by the Swiss National Science Foundation, and E. M. by an NIH-Fogarty International Fellowship.",

year = "1980",

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doi = "10.1016/0091-3057(80)90353-6",

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T2 - Effect of amphetamine, apomorphine, and DOPA

AU - Hefti, Franz

AU - Melamed, Eldad

AU - Sahakian, Barbara J.

AU - Wurtman, Richard J.

N1 - Funding Information: This study was supported in part by the National Institutes of Health and the American Parkinson's Disease Association. F. H. was supported by the Swiss National Science Foundation, and E. M. by an NIH-Fogarty International Fellowship.

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AB - Partial, unilateral lesions of the nigro-striatal tract were produced in rats by injecting various quantities of 6-hydroxydopamine into the substantia nigra. The extent of each animal's lesion was estimated by comparing tyrosine hydroxylase activities in its lesioned and control striata. L-DOPA and apomorphine induced contralateral (i.e., away from the lesion) circling behavior only in rats in which more than 90% of the nigro-striatal system had been destroyed. In contrast, d-amphetamine caused turning in the ipsilateral direction when as few as 50% of the nigro-striatal neurons had been destroyed.

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KW - Dopamine

KW - Nigro-striatal neurons

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Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

Abstract

Keywords

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