Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

Franz Hefti, Eldad Melamed, Barbara J. Sahakian, Richard J. Wurtman

Research output: Contribution to journalArticlepeer-review

Abstract

Partial, unilateral lesions of the nigro-striatal tract were produced in rats by injecting various quantities of 6-hydroxydopamine into the substantia nigra. The extent of each animal's lesion was estimated by comparing tyrosine hydroxylase activities in its lesioned and control striata. L-DOPA and apomorphine induced contralateral (i.e., away from the lesion) circling behavior only in rats in which more than 90% of the nigro-striatal system had been destroyed. In contrast, d-amphetamine caused turning in the ipsilateral direction when as few as 50% of the nigro-striatal neurons had been destroyed.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume12
Issue number2
DOIs
StatePublished - Feb 1980
Externally publishedYes

Keywords

  • 6-Hydroxydopamine
  • Amphetamine
  • Apomorphine
  • Circling behavior
  • DOPA
  • Dopamine
  • Nigro-striatal neurons
  • Rats

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