Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine

Isabelle C. Weiss, Joram Feldon*, Annette M. Domeney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The present study investigated the influence of circadian time (experimental testing during the light or dark phase of the light:dark cycle) on the acoustic startle response (ASR), prepulse inhibition (PPI), and apomorphine-induced PPI deficits in Wistar rats housed under a reversed light:dark cycle (lights off at 0700 h and on at 1900 h). There was no significant difference in the startle response amplitude or PPI response of animals tested during the light phase compared with those tested during the dark phase. Similarly, the response to apomorphine (0.01-0.05 mg/kg subcutaneously) was not modulated by circadian time. Thus, under the conditions adopted in the present study, ASR, PPI, and apomorphine-induced PPI deficits remained stable across the circadian cycle. Such findings may be of importance for other investigators using the PPI paradigm to study brain plasticity mechanisms and pharmacological manipulations of apomorphine-induced PPI deficits in rats housed under normal or reversed light:dark cycle conditions. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)501-505
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume64
Issue number3
DOIs
StatePublished - Nov 1999
Externally publishedYes

Funding

FundersFunder number
Hoffmann–LaRoche

    Keywords

    • Apomorphine
    • Circadian time
    • Prepulse inhibition
    • Wistar rat

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