Circadian rhythm disorders

Katy Borodkin, Yaron Dagan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The majority of patients with circadian rhythm sleep disorders (CRSD) report that the disorder typically began in early childhood or adolescence. The diagnosis of CRSDs can be established through three procedures: clinical interview, longitudinal monitoring of the sleep-wake cycle, and assessment of biological markers of the internal circadian rhythmicity. Bright light therapy and melatonin treatment, or a combination of these two, have proved to be the most effective treatment modalities for patients with CRSDs. This chapter reviews the disorders that have been systematically examined with regard to CRSDs, specifically mood disorders, attention-deficit/hyperactivity disorder (ADHD), personality disorders, and obsessive-compulsive disorder (OCD). Several cases of disrupted sleep-wake schedule as iatrogenic effects of psychoactive drugs are documented in the literature. Switching treatment to the atypical neuroleptic clozapine established a more organized and stable sleep-wake pattern and improved the clinical state of the patient.
Original languageAmerican English
Title of host publicationFoundations of Psychiatric Sleep Medicine
EditorsDavid T. Plante, John W. Winkelman
Place of PublicationCambridge
PublisherCambridge University Press
Number of pages17
ISBN (Electronic)9780511777493
ISBN (Print)9780521515115
StatePublished - 2010


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